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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
10.3
Human Site:
S421
Identified Species:
17.44
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
S421
G
K
L
K
N
V
Q
S
E
T
K
G
R
A
K
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
S421
G
K
L
K
N
V
Q
S
E
T
K
G
R
A
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
Q518
K
G
K
L
K
N
V
Q
S
E
T
K
R
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
N415
K
M
K
G
K
L
K
N
V
Q
L
N
T
K
S
Rat
Rattus norvegicus
NP_001099948
974
110023
S386
F
S
K
R
R
K
I
S
V
Q
S
T
E
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
S376
Q
F
G
Q
H
L
K
S
D
V
H
L
N
F
Y
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
P411
E
E
D
E
G
W
L
P
R
K
V
K
A
T
A
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
K401
V
P
S
K
K
C
V
K
K
S
S
V
P
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
L469
I
L
A
D
D
M
G
L
G
K
T
L
T
M
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
S497
G
P
S
Q
P
V
A
S
L
P
G
P
S
P
P
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
S291
V
C
P
P
A
V
F
S
T
W
I
T
Q
L
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
I373
P
S
V
I
S
A
W
I
T
Q
L
E
E
H
T
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
T282
Q
G
Y
D
V
V
L
T
T
Y
A
V
L
E
S
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
L579
Q
H
C
L
G
G
I
L
A
D
E
M
G
L
G
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
100
N.A.
13.3
N.A.
0
6.6
N.A.
6.6
N.A.
0
6.6
N.A.
0
N.A.
N.A.
20
P-Site Similarity:
100
100
N.A.
13.3
N.A.
20
20
N.A.
40
N.A.
13.3
33.3
N.A.
13.3
N.A.
N.A.
26.6
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
13.3
N.A.
N.A.
0
6.6
0
P-Site Similarity:
26.6
N.A.
N.A.
13.3
13.3
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
8
8
0
8
0
8
0
8
15
8
% A
% Cys:
0
8
8
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
15
8
0
0
0
8
8
0
0
0
0
0
% D
% Glu:
8
8
0
8
0
0
0
0
15
8
8
8
15
8
15
% E
% Phe:
8
8
0
0
0
0
8
0
0
0
0
0
0
8
0
% F
% Gly:
22
15
8
8
15
8
8
0
8
0
8
15
8
0
8
% G
% His:
0
8
0
0
8
0
0
0
0
0
8
0
0
8
0
% H
% Ile:
8
0
0
8
0
0
15
8
0
0
8
0
0
0
8
% I
% Lys:
15
15
22
22
22
8
15
8
8
15
15
15
0
8
22
% K
% Leu:
0
8
15
15
0
15
15
15
8
0
15
15
8
15
0
% L
% Met:
0
8
0
0
0
8
0
0
0
0
0
8
0
8
0
% M
% Asn:
0
0
0
0
15
8
0
8
0
0
0
8
8
0
0
% N
% Pro:
8
15
8
8
8
0
0
8
0
8
0
8
8
8
8
% P
% Gln:
22
0
0
15
0
0
15
8
0
22
0
0
8
0
0
% Q
% Arg:
0
0
0
8
8
0
0
0
8
0
0
0
22
0
0
% R
% Ser:
0
15
15
0
8
0
0
43
8
8
15
0
8
15
22
% S
% Thr:
0
0
0
0
0
0
0
8
22
15
15
15
15
8
8
% T
% Val:
15
0
8
0
8
36
15
0
15
8
8
15
0
8
0
% V
% Trp:
0
0
0
0
0
8
8
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _